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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IF/ICC, FC, ELISA | 56 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IF/ICC=1:100-500 FC=1:50-200 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | BACE1 Mouse Monoclonal Antibody detects endogenous levels of BACE1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
BACE1 also konwn as Beta secretase 1 is a member of the peptidase A1 family of aspartic proteases. BACE1 plays a crucial role in the pathogenesis of Alzheimer′s disease by cleaving the amyloid precursor protein (APP) to produce amyloid beta-peptide (Aβ), which aggregates to form amyloid plaques, a hallmark of the disease. BACE1 localization within the Golgi apparatus and endosomes is particularly important, as these cellular compartments facilitate APP processing, leading to Aβ generation. Understanding BACE1 cellular location is vital for developing therapeutic strategies aimed at inhibiting BACE1 activity, thereby potentially reducing Aβ production and mitigating the progression of Alzheimer′s disease. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, HepG2, PC12, NIH/3T3 cells, using BACE1 Mouse Monoclonal Antibody (EAB21855) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Predicted band size: 56 kDa; Observed band size: 70 kDa |
