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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, IF/ICC, ELISA | 67 | Human, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:100-500 IF/ICC=1:100-500 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TORC3/CRTC3 Mouse Monoclonal Antibody detects endogenous levels of TORC3/CRTC3 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TORC3 also known as CTRC3 is a member of the CREB regulated transcription coactivator gene family. TORC3 plays a crucial role in cellular signaling and gene expression regulation. TORC3 is primarily located in both the cytoplasm and nucleus, which enables interaction with various transcription factors and modulation of gene expression in response to cellular signals. TORC3 acts as a transcriptional coactivator for CREB-1, influencing the expression of genes activated by CREB, and is involved in the SIK/TORC signaling pathway, which is essential for processes such as energy metabolism and stress response. TORC3 is expressed in various tissues, including lung, colon, brain, ovary, kidney, prostate, and heart, and is particularly important in lymphocytes, where TORC3 contributes to immune responses. Multiple alternatively spliced isoforms of TORC3 further underscore functional diversity and regulatory potential in different cellular contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, COS7, MCF7, Jurkat cells, using TORC3/CRTC3 Mouse Monoclonal Antibody (EAB21935) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue, using TORC3/CRTC3 Mouse Monoclonal Antibody (EAB21935) at 1:200 dilution.
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