| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 27 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CLIC1 Rabbit Polyclonal Antibody detects endogenous levels of CLIC1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CLIC1 also known as NCC27, G6 is a crucial member of a highly conserved family of chloride ion channels that can exist in both soluble and integral membrane forms. CLIC1 is primarily located in the cytoplasm and can translocate to the plasma membrane, where CLIC1 plays a vital role in regulating chloride ion transport across cellular membranes. This transport is essential for maintaining cellular homeostasis, influencing processes such as cell volume regulation, signal transduction, and muscle contraction. Notably, CLIC1′s ability to form anion-selective channels is modulated by redox state; CLIC1 exists as a monomer in a reduced environment but dimerizes upon oxidation, facilitating channel formation in lipid bilayers and vesicles. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, U937, Rat kidney cells, using CLIC1 Rabbit Polyclonal Antibody (EAB12170) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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