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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 77 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | FE65/APBB1 Rabbit Polyclonal Antibody detects endogenous levels of FE65/APBB1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
FE65 also known as APBB1 is a member of the Fe65 protein family. FE65 plays a crucial role in the processing of amyloid precursor protein (APP), which is essential for understanding Alzheimer′s disease pathology. FE65 interacts with the cytoplasmic tail of APP, specifically binding to the YENPTY motif, which is vital for the regulation of APP trafficking and the subsequent secretion of β-Amyloid. This interaction not only enhances the translocation of APP to the cell surface but also influences cell motility through its association with Mena, a cell-adhesion protein. FE65 is predominantly expressed in the brain, particularly in regions such as the hippocampus and isocortex, and Fe65 localization to the endoplasmic reticulum and Golgi apparatus underscores its importance in cellular signaling pathways related to neurodegeneration. |
| Product Image Gallery | |
 Western blot analysis of extracts on Mouse brain cells, using FE65/APBB1 Rabbit Polyclonal Antibody (EAB11766) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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