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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 131 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | HIPK2 Rabbit Polyclonal Antibody detects endogenous levels of HIPK2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HIPK2 is a member of the HIPK family, which includes HIPK1 and HIPK3, and is characterized by a conserved protein kinase domain that interacts with homeoproteins. HIPK2 functions as a co-repressor of homeodomain transcription factors, influencing gene expression and developmental pathways. HIPK2 regulates apoptosis and cellular stress responses, maintaining cellular homeostasis. HIPK2 localizes primarily in the nucleus, participating in nuclear body formation involved in gene expression regulation and stress response. HIPK2 presence in nuclear structures underscores a significant role in cellular signaling pathways and potential involvement in cancer and autoimmunity. HIPK2 undergoes SUMO-1 conjugation, enhancing stability and function while directing nuclear body localization crucial for stress and viral infection responses. Such modification influences protein interactions and cellular activity. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T cells, using HIPK2 Rabbit Polyclonal Antibody (EAB11778) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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