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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC | 85 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:1000-5000 IHC-P=1:100-500 IF/ICC=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Ezh2 Rabbit Monoclonal Antibody detects endogenous levels of Ezh2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Ezh2 also known as ENX-1, KMT6 is a member of the Polycomb group (PcG) gene family. Ezh2 plays a crucial role in regulating gene expression during embryonic development by repressing homeotic loci, which is essential for proper body plan formation. Ezh2 is predominantly expressed during early embryogenesis and later becomes localized to the central and peripheral nervous systems, as well as sites of fetal hematopoiesis, highlighting Ezh2′s importance in both developmental and adult tissue contexts. Ezh2 interacts with the proto-oncogene product Vav, suggesting involvement in the proliferation of both normal and malignant hematopoietic cells. Alterations in the regulation of target genes by Ezh2 may contribute to specific phenotypes associated with Down syndrome, underscoring Ezh2′s significance in both health and disease. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, C6, Jurkat, NIH/3T3 cells, using Ezh2 Rabbit Monoclonal Antibody (EAB21970) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 85 kDa; Observed band size: 78-110 kDa |
