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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Mouse IgG1 | Monoclonal | WB, IHC-P, ELISA | 71 | Human, Mouse, Monkey |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:100-500 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MYST2/HBO1 Mouse Monoclonal Antibody detects endogenous levels of MYST2/HBO1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
HBO1 also known as MYST2, KAT7 is a member of the MYST family of histone acetyltransferases, which play a crucial role in regulating transcription through chromatin modification. HBO1 is primarily located in the nucleus and is highly expressed in human testis, where HBO1 is involved in histone acetylation, thereby influencing gene expression and DNA replication. HBO1 interacts with ORC1, the largest subunit of the origin recognition complex, which is essential for initiating DNA replication. By mediating histone acetylation, HBO1 not only facilitates gene transcription but also represses androgen receptor-mediated transcription, indicating a potential role in regulating gene expression in both normal physiology and prostate cancer. HBO1′s ability to modulate these critical processes underscores its importance in cellular function and highlights its relevance as a target for research in cancer biology and transcriptional regulation. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, U251, HepG2, NIH/3T3 cells, using MYST2/HBO1 Mouse Monoclonal Antibody (EAB21973) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue, using MYST2/HBO1 Mouse Monoclonal Antibody (EAB21973) at 1:200 dilution.
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