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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IP, IHC-P, IF/ICC | 31 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IP=1:10-100 IHC-P=1:50-200 IF/ICC=1:50-200 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MTAP Rabbit Monoclonal Antibody detects endogenous levels of MTAP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MTAP an enzyme that plays a crucial role in polyamine metabolism and the salvage pathways for adenine and methionine, which are vital for cellular growth and function. Located in the cytoplasm, MTAP is essential for maintaining cellular homeostasis and regulating polyamine levels, which are important for cell proliferation and differentiation. The gene encoding MTAP is situated on human chromosome 9p21, closely linked to the tumor suppressor gene p16INK4A, and MTAP deficiency is often observed in various cancers due to the co-deletion of both genes. This loss can lead to increased susceptibility to malignancy, as cells lacking MTAP may be more vulnerable to growth-inhibitory agents, such as antifolates, that exploit the adenine salvage pathway. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, Mouse spleen cells, using MTAP Rabbit Monoclonal Antibody (EAB22134) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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