www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 53 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MetAP2 Rabbit Polyclonal Antibody detects endogenous levels of MetAP2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MetAP2 is a member of the methionyl aminopeptidase family. MetAP2 plays a crucial role in protein maturation by removing N-terminal methionine residues from nascent peptides, a process essential for proper folding and function of many proteins. MetAP-2 enzymatic activity regulates cell proliferation through various cellular processes that influence growth and differentiation. Neurofibromin (NF1) tightly regulates MetAP2 expression, and increased MetAP2 levels have been associated with several types of cancer, making MetAP2 a significant target for therapeutic intervention. MetAP2 inhibitors, such as ovalicin and fumagillin, have shown promise in cancer treatment by blocking MetAP2 activity, thereby potentially hindering tumor proliferation, especially in NF1-associated malignancies. |
| Product Image Gallery | |
 Western blot analysis of extracts on NIH/3T3, Mouse testis cells, using MetAP2 Rabbit Polyclonal Antibody (EAB11954) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
