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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 42 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | MBNL1 Rabbit Polyclonal Antibody detects endogenous levels of MBNL1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MBNL1 is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. MBNL1 is a crucial protein involved in the regulation of pre-mRNA splicing, which is essential for the proper expression of genes. This 370 amino acid protein is predominantly expressed in various tissues, including skeletal muscle, prostate, lung, heart, small intestine, ovary, and placenta, highlighting its significance in diverse biological processes. MBNL1 plays a vital role in the splicing of pre-mRNAs by interacting with other splicing factors, thereby influencing the inclusion or exclusion of specific exons. Notably, MBNL1 and its homolog MBNL2 are implicated in myotonic dystrophy types 1 and 2, as MBNL1 localizes to nuclear foci formed by expanded CUG repeats, suggesting that the accumulation of mutant RNA in the nucleus contributes to the pathogenesis of these disorders. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, Jurkat, HepG2 cells, using MBNL1 Rabbit Polyclonal Antibody (EAB14430) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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