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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 6 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Noxa Rabbit Polyclonal Antibody detects endogenous levels of NOXA protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NOXA also known as ARP, PMAIP1 is a pro-apoptotic member of the Bcl-2 family, contains the Bcl-2 homology 3 (BH3) region, but does not contain other BH domains. NOXA plays a crucial role in regulating programmed cell death, which is vital for maintaining cellular homeostasis and preventing tumorigenesis. NOXA contains the Bcl-2 homology 3 (BH3) domain, which is essential for promoting apoptosis, while lacking other BH domains present in anti-apoptotic proteins. NOXA is selectively localized to the mitochondria, where NOXA interacts with other Bcl-2 family members to modulate apoptotic signaling pathways. This mitochondrial localization positions NOXA to directly influence the release of cytochrome c and other pro-apoptotic factors, thereby initiating the apoptotic cascade. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T cells, using Noxa Rabbit Polyclonal Antibody (EAB11757) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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