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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 36 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Nek6 Rabbit Polyclonal Antibody detects endogenous levels of Nek6 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Nek6 is a kinase required for progression through the metaphase portion of mitosis. Nek6 plays a crucial role in cell division, particularly during metaphase-anaphase transition, where Nek6 is essential for proper chromosome segregation and mitotic progression. This function maintains genomic stability, as errors in chromosome segregation can lead to aneuploidy and contribute to tumorigenesis. Nek6 is predominantly localized in cytoplasm and exhibits ubiquitous expression, with highest levels found in heart and skeletal muscle, highlighting Nek6′s importance in tissues with high proliferative demands. Nek6 is activated during M phase of cell cycle, underscoring Nek6′s role in regulating mitotic events. |
| Product Image Gallery | |
 Western blot analysis of extracts on U2OS cells, using Nek6 Rabbit Polyclonal Antibody (EAB11801) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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