| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 58 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Nectin 2 Rabbit Polyclonal Antibody detects endogenous levels of Nectin 2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Nectin 2 also known as PVRL2, CD116 is a member of the nectin family, which plays a significant role in cell adhesion and communication, particularly in viral entry mechanisms. Nectin 2 is predominantly expressed in various human cell types, including neuronal cell lines, fibroblasts, keratinocytes, and activated T lymphocytes, highlighting its importance in both neural and immune responses. Nectin 2 exists in two splicing variants, Nectin 2α and Nectin 2δ, which differ in their cytoplasmic and transmembrane regions while sharing identical extracellular domains. The C-terminal conserved motif present in both variants is essential for interaction with the PDZ domain of afadin, linking Nectin 2 to the actin cytoskeleton and facilitating cellular adhesion. Nectin 2 mediates the entry of specific herpes simplex virus strains, underscoring its role in viral pathogenesis and potential implications in therapeutic strategies. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, Mouse brain cells, using Nectin 2 Rabbit Polyclonal Antibody (EAB11805) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 58 kDa; Observed band size: 65 kDa |
