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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Monoclonal | WB, IHC-P, IF/ICC, FC | 12 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-200 IF/ICC=1:50-200 FC=1:10-100 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PEN2 Rabbit Monoclonal Antibody detects endogenous levels of PEN2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PEN2 also known as PSENEN is a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. PEN2 plays a crucial role in the assembly and function of the gamma-secretase complex, which is essential for the proteolytic processing of type I membrane proteins, including the amyloid-beta precursor protein. This processing is particularly significant as PEN2 is linked to the pathogenesis of Alzheimer′s disease, where the accumulation of amyloid-beta peptides is a hallmark. The gamma-secretase complex, composed of presenilin, nicastrin, aph-1, and PEN2, assembles in the Golgi/trans-Golgi network compartments, leading to the autocleavage of presenilin into two subunits that form the active site of gamma-secretase. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela, SH-SY5Y, A549, 293T cells, using PEN2 Rabbit Monoclonal Antibody (EAB22113) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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