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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 79 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | RAP80/UIMC1 Rabbit Polyclonal Antibody detects endogenous levels of RAP80/UIMC1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
RAP80(Receptor Associated Protein 80) also konwn as UIMC1 is a nuclear protein that plays a critical role in the DNA damage response pathway. RAP80 interacts with Brca1 (breast cancer 1) in a complex to recognize and repair DNA lesions. Research studies indicate that the absence of RAP80 in cells results in increased sensitivity to the topoisomerase II inhibitor etoposide. In the absence of functional RAP80, BRCA1 A complex function is suppressed and cells become more sensitive to DNA damage-induced genome instability. RAP80 binds ubiquitinated lysine 63 of histone H2A and H2AX. RAP80 may also function as a repressor of transcription. |
| Product Image Gallery | |
 Western blot analysis of extracts on COLO205 cells, using RAP80/UIMC1 Rabbit Polyclonal Antibody (EAB14952) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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