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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 35 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CHIP/STUB1 Rabbit Polyclonal Antibody detects endogenous levels of CHIP/STUB1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CHIP also known as STUB1 is a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. CHIP plays a crucial role in protein quality control by mediating the ubiquitination and subsequent degradation of misfolded or damaged proteins. This function is vital for maintaining cellular homeostasis and preventing the accumulation of potentially toxic proteins that can lead to disease. CHIP interacts with molecular chaperones Hsp70 and Hsp90, facilitating the degradation of client proteins such as ErbB2 and CFTR, which is significant in regulating signaling pathways and stress responses. Additionally, CHIP can modulate signaling pathways by interacting with Smad1/Smad4 and inhibiting BMP signaling through the ubiquitin-mediated degradation of Smad proteins. |
| Product Image Gallery | |
 Western blot analysis of extracts on PC12 cells, using CHIP/STUB1 Rabbit Polyclonal Antibody (EAB11839) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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