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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 52 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TRIM21 Rabbit Polyclonal Antibody detects endogenous levels of TRIM21 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TRIM21 also known as SSA, RO52 is a member of the tripartite motif (TRIM) family. TRIM21 plays a crucial role in immune response, particularly in autoimmune diseases such as systemic lupus erythematosus and Sjogren′s syndrome, where autoantibodies recognize TRIM21 in many patients. TRIM21 protein primarily localizes in cellular cytoplasm and nucleus, regulating RNA metabolism and immune response through interactions with RNA molecules and other proteins to form essential ribonucleoprotein complexes. Antibodies against TRIM21 appear in most patients with primary Sjögren syndrome and related autoimmune conditions, highlighting clinical significance in disease pathology. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using TRIM21 Rabbit Polyclonal Antibody (EAB14951) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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