www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 48 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | TEAD1 Rabbit Polyclonal Antibody detects endogenous levels of TEAD1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
TEAD1 also known as TEF-1, TCF-13 is a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. TEAD1′s highly conserved DNA-binding domain allows interaction with specific DNA sequences, such as GT-IIC, SphI/II, and M-CAT, as well as the proximal regulatory element of transforming growth factor-alpha, which is often overexpressed in numerous cancers. TEAD1′s ability to bind these elements is vital for function in gene regulation, particularly in tumorigenesis, where TEAD1 may influence oncogene expression. Additionally, TEAD1 undergoes post-translational modifications, including phosphorylation by several protein kinase C isozymes, which occurs at serine and threonine residues. This phosphorylation can diminish DNA-binding capacity, suggesting a regulatory mechanism that may inhibit transcriptional activity. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562, COLO205 cells, using TEAD1 Rabbit Polyclonal Antibody (EAB11830) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
