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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 46 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PLEKHA1 Rabbit Polyclonal Antibody detects endogenous levels of PLEKHA1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PLEKHA1 also known as TAPP1 is a pleckstrin homology domain-containing adapter protein. PLEKHA1 plays a significant role in cellular signaling pathways. PLEKHA1 is predominantly expressed in tissues such as skeletal muscle, spleen, lung, thymus, and placenta, where PLEKHA1 is involved in the regulation of actin-mediated membrane dynamics. Upon stimulation by growth factors and subsequent activation of phosphoinositol 3-kinase, PLEKHA1 is recruited to the plasma membrane, where PLEKHA1 accumulates in F-actin-rich membrane ruffles. This recruitment is facilitated by the specific interaction of PLEKHA1 C-terminal PH domain with phosphatidylinositol 3,4-bisphosphate, highlighting the importance of lipid-protein interactions in cellular signaling. |
| Product Image Gallery | |
 Western blot analysis of extracts on SW480 cells, using PLEKHA1 Rabbit Polyclonal Antibody (EAB14933) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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