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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 60 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | USP22 Rabbit Polyclonal Antibody detects endogenous levels of USP22 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
USP22 (ubiquitin specific peptidase 22) also known as USP3L is a 525 amino acid protein characterized by the presence of a UBP-type zinc finger, which is crucial for enzymatic activity. USP22 plays a significant role in the ubiquitin-proteasome pathway, a vital cellular mechanism that regulates protein degradation and turnover, thereby influencing various cellular processes such as signal transduction, transcriptional activation, and cell cycle progression. USP22 catalyzes the conversion of ubiquitin C-terminal thioesters to free ubiquitin and thiol, maintaining cellular homeostasis and potentially acting as a marker for cancer stem cells, highlighting potential importance in cancer biology. USP22 is encoded on human chromosome 17, a region encompassing over 2.5% of the human genome and responsible for encoding more than 1,200 genes, underscoring complexity and significance in various biological contexts. |
| Product Image Gallery | |
 Western blot analysis of extracts on HEK293, Mouse tests cells, using USP22 Rabbit Polyclonal Antibody (EAB11948) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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