Protein Agonists, Antagonists and Activators - Irinotecan hydrochloride trihydrate (CAS: 136572-09-3)

Irinotecan hydrochloride trihydrate (CAS: 136572-09-3)

Catalog #：EBC51163

Biological Activity

Synonyms

Camptosar; Campto; CPT-11

Chemical Name

(S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate hydrochloride trihydrate

Application

Irinotecan hydrochloride trihydrate is an inhibitor of Topo I

CAS Number

136572-09-3

Purity

≥99.0%

Molecular Weight

677.18

Molecular Formula

C₃₃H₄₅ClN₄O₉

SMILES

O=C(N1CCC(CC1)N2CCCCC2)OC3=CC4=C(CC)C5=C(C(N6C5)=CC(C7(CC)O)=C(COC7=O)C6=O)N=C4C=C3.Cl.O.O.O

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.4767 ml	7.3836 ml	14.7671 ml
5 mM	0.2953 ml	1.4767 ml	2.9534 ml
10 mM	0.1477 ml	0.7384 ml	1.4767 ml
50 mM	0.0295 ml	0.1477 ml	0.2953 ml

Solubility
DMSO: 50 mg/mL (73.84 mM) Water: 1.52 mg/mL (2.24 mM; Need ultrasonic and warming)

Product Description

Irinotecan hydrochloride trihydrate, Irinotecan (CPT 11), a compound within the camptothecin family, is an inhibitor of Topo I (topoisomerase I) involved in cellular DNA replication and transcription. As a Topo I inhibitor, Irinotecan inhibits the religation step of the enzyme's normal action, inducing single stranded DNA breaks. These single stranded breaks are then converted to double-stranded breaks within the course of DNA replication which is reported to induce apoptosis or repair mechanisms as a result. Irinotecan is activated by esterases to produce the activated metabolite, SN 38 (sc-203697) and has been reported to be associated with cleavage of poly (ADP-ribose) polymerase (PARP) in colon carcinoma cells. Irinotecan's active metabolite SN 38 is additionally noted to activate p53 in the Huh7 cell line.