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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 63 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | tPA Rabbit Polyclonal Antibody detects endogenous levels of tPA protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
tPA also known as PLAT is a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. tPA plays a crucial role in the fibrinolytic system, primarily facilitating the breakdown of fibrin in blood clots, which is essential for maintaining normal blood flow and preventing excessive clot formation. tPA is secreted by endothelial cells and is found in the bloodstream, where tPA acts to convert plasminogen into plasmin, the active enzyme responsible for degrading fibrin. The regulation of tPA is vital, as an imbalance can lead to pathological conditions such as thrombosis or hemorrhage. Additionally, tPA interacts with various proteins, including plasminogen activator inhibitor-1 (PAI-1), which modulates tPA activity and stability. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using tPA Rabbit Polyclonal Antibody (EAB13014) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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