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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 45 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IL-11Rα Rabbit Polyclonal Antibody detects endogenous levels of IL-11Rα protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IL-11Rα also known as IL11RA is a stromal cell-derived cytokine that plays a crucial role in mediating the effects of the pleiotropic cytokine IL-11, which influences the proliferation and differentiation of lymphopoietic, myeloid, and erythroid cells. IL-11 has been shown to inhibit adipogenesis in vitro, highlighting IL-11′s importance in metabolic regulation. IL-11Rα receptor is a member of the class I cytokine receptor family and shares structural similarities with the alpha subunits of human ciliary neurotrophic factor and mouse IL-6 receptor. This structural similarity suggests a conserved mechanism of action among these receptors. High-affinity binding of IL-11 to IL-11Rα requires glycoprotein 130 (gp130) coexpression, which is essential for proper stimulation of Ba/F3 cells to differentiate into macrophages in response to IL-11. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using IL-11Rα Rabbit Polyclonal Antibody (EAB13124) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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