| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 96 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | IL-17Rα Rabbit Polyclonal Antibody detects endogenous levels of IL-17Rα protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
IL-17Rα also knonw as IL17R, IL17RA is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17Rα plays a crucial role in mediating the effects of the pro-inflammatory cytokine IL-17, which is essential for the immune response and the regulation of inflammation. IL-17Rα is predominantly expressed in the spleen and kidney, highlighting its importance in immune system function and tissue homeostasis. Upon binding with IL-17, IL-17Rα activates downstream signaling pathways that lead to the production of various pro-inflammatory cytokines, including IL-6 and IL-8, thereby amplifying the inflammatory response. This interaction is vital for the host defense against pathogens, but dysregulation can contribute to autoimmune diseases and chronic inflammatory conditions. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using IL-17Rα Rabbit Polyclonal Antibody (EAB13125) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 96 kDa; Observed band size: 90 kDa |
