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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 133 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Jagged2 Rabbit Polyclonal Antibody detects endogenous levels of Jagged2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Jagged2 also known as JAG2 is a member of the LIN-12/Notch family of transmembrane receptors, plays a pivotal role in developmental processes by influencing cell fate decisions. Jagged2 protein is primarily located in the cell membrane, where Jagged2 functions as a ligand for Notch receptors, thereby activating signaling pathways essential for various biological processes, including cardiovascular development and hematopoiesis. The interaction between Jagged2 and Notch is crucial, as this interaction not only regulates cell differentiation but also prevents myoblasts from maturing into muscle cells by inhibiting muscle-specific genes. Jagged2 expression is notably up-regulated in certain pathological conditions, such as cervical squamous cell carcinoma, highlighting Jagged2′s potential role in tumorigenesis. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using Jagged2 Rabbit Polyclonal Antibody (EAB13162) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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