www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 134 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | ZO-2 Rabbit Polyclonal Antibody detects endogenous levels of ZO-2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
ZO-2 also known as TJP2 is a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. ZO-2 plays a crucial role in forming and maintaining tight junctions, which are essential for regulating paracellular permeability and maintaining epithelial and endothelial barrier integrity. Tight junctions comprise various proteins, including ZO-2, ZO-1, and claudins, that work together to create a selective barrier controlling ion and molecule movement between cells. Proper functioning of ZO-2 is vital for tissue homeostasis and cellular signaling, as disruptions in tight junction integrity can lead to various pathologies, including cancer metastasis and inflammatory diseases. ZO-2 is specifically localized at tight junctions of epithelial cells, where ZO-2 interacts with other tight junction proteins and actin cytoskeleton, contributing to structural stability and dynamic regulation of these junctions. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using ZO-2 Rabbit Polyclonal Antibody (EAB13168) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
