www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 110 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PIWIL2 Rabbit Polyclonal Antibody detects endogenous levels of PIWIL2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PIWIL2 also known as HILI, CT80 is a member of the argonaute family, characterized by the presence of one PAZ domain and one PIWI domain. This cytoplasmic protein is predominantly expressed in adult testis and various tumors, playing a crucial role in regulating spermatogenesis and the production of primordial germ cells. PIWIL2 is involved in the meiotic differentiation of spermatocytes and the self-renewal of spermatogonial stem cells, which is vital for maintaining male fertility. PIWIL2 interacts with several key proteins that influence cellular processes, including PDGFR-β, which is associated with stem cell proliferation, and Glut1, which is involved in energy metabolism. PIWIL2 may act as a regulatory factor in the Stat3/Bcl-xS/L/CCND1 signaling pathway, and PIWIL2 repression has been shown to inhibit tumor cell growth, highlighting a potential role as an oncogene by promoting proliferation and inhibiting apoptosis in cancerous cells. |
| Product Image Gallery | |
 Western blot analysis of extracts on Hela cells, using PIWIL2 Rabbit Polyclonal Antibody (EAB13175) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
