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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 93 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-CDCP1/CD318 (Tyr743) Rabbit Polyclonal Antibody detects endogenous levels of CDCP1/CD318 protein only when phosphorylated at Tyr743. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CDCP1 also known as CD318 plays a crucial role in cellular signaling and is involved in processes such as cell adhesion and migration, which are vital for tissue repair and cancer metastasis. CDCP1 is primarily located in the plasma membrane, where three extracellular CUB domains facilitate interactions with other proteins and extracellular matrix components, thereby influencing cellular behavior in response to environmental cues. CDCP1 is highly expressed in metastatic colon and breast tumors, making CDCP1 a significant marker for hematopoietic cells and a potential target for therapeutic interventions. Phosphorylation of CDCP1 by Src family kinases at specific tyrosine residues, including Tyr 734, enhances signaling capabilities, which can impact the progression of epithelial wounds and tumorigenesis. |
