| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 72 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DR6 Rabbit Polyclonal Antibody detects endogenous levels of DR6 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DR6 also known as TNFRSF21 is a member of the tumor necrosis factor receptor superfamily and plays a crucial role in mediating apoptosis and inflammatory responses. DR6 interacts with TRAIL ligand to initiate apoptotic signaling pathways. This interaction is vital for regulating cell death and maintaining tissue homeostasis, as dysregulation of DR6 signaling can lead to various diseases, including cancer and autoimmune disorders. A death domain in DR6 is essential for function, allowing signal transduction of apoptotic signals effectively. Understanding DR6′s role in cellular processes provides insights into function and highlights potential therapeutic targeting in diseases characterized by aberrant apoptosis. |
| Product Image Gallery | |
 Western blot analysis of extracts on PC12, Rat brain cells, using DR6 Rabbit Polyclonal Antibody (EAB13282) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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