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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 86 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SATB1 Rabbit Polyclonal Antibody detects endogenous levels of SATB1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SATB1 is a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. SATB1 plays a crucial role in regulating gene expression, particularly during cell development and differentiation. SATB1 is primarily expressed in thymocytes and contains a unique homeobox DNA-binding domain essential for DNA interaction. SATB1′s structure includes an additional domain exhibiting high affinity for DNA, allowing specific binding to nuclear matrix attachment regions (MARs) of DNA. These MARs are critical for organizing chromosomal loops and regulating transcription and replication within the nucleus. SATB1′s interaction with MARs is vital for maintaining genome structural integrity and ensuring proper gene expression, making SATB1 an important factor in cellular function and development. SATB1′s ability to synergistically interact with other transcriptional repressors, such as CCAAT displacement protein (CDP), further underscores SATB1′s significance in mediating complex gene regulatory networks. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using SATB1 Rabbit Polyclonal Antibody (EAB13361) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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