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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 238 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-NumA (Thr2055) Rabbit Polyclonal Antibody detects endogenous levels of NumA protein only when phosphoryated at Thr2055. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
NumA also known as NumA1 plays a critical role in organizing and stabilizing spindle poles during mitosis, which is essential for accurate chromosome segregation. Mapping to chromosome 11q13, NuMA gene encodes a noncentrosomal protein that binds to microtubules through its carboxyl terminal region, facilitating bipolar spindle formation by aggregating microtubules and interacting with motor proteins. This function is vital for maintaining genomic stability, as errors in spindle assembly can lead to aneuploidy and contribute to tumorigenesis. NuMA protein is predominantly localized to the spindle apparatus during mitosis, yet also appears in the nucleus and cytoplasm of post-mitotic neurons, indicating diverse roles in different cell types. |
