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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | IHC-P, IF, ELISA | 55 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-MYT1 (Ser83) Rabbit Polyclonal Antibody detects endogenous levels of MYT1 protein only when phosphorylated at Ser83. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MYT1 also known as PKMTY1 is a member of the serine/threonine protein kinase family. MYT1 plays a crucial role in cell cycle regulation, specifically in the phosphorylation of Cdc2, a key protein that controls the transition from G2 phase to mitosis. MYT1 phosphorylates Cdc2 on threonine 14 and tyrosine 15, which is essential for keeping Cdc2 in an inactive state during S and G2 phases of the cell cycle. This regulation is vital for ensuring proper cell division and preventing premature mitotic entry, which could lead to genomic instability. MYT1 activity is tightly controlled throughout the cell cycle, and MYT1 interaction with other proteins, such as Wee 1 kinase, highlights MYT1′s importance in the mitotic control network. Dephosphorylation of Cdc2 by Cdc25 in late G2 phase activates the Cdc2/cyclin B complex, allowing cells to progress into mitosis. |
| Product Image Gallery | |
 Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using Phospho-MYT1 (Ser83) Rabbit Polyclonal Antibody (EAB13423) at 1:100 dilution.
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