| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, ELISA | 95 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-LSD1 (Ser131) Rabbit Polyclonal Antibody detects endogenous levels of LSD1 only when phosphorylated at Ser131. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
LSD1 also known as AOF2, BHC110, KDM1A a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 plays a crucial role in regulating chromatin structure and transcription by removing methyl groups from histone H3, thereby influencing gene expression and maintaining the epigenetic state of the cell. LSD1′s ability to dynamically regulate histone methylation is vital for cellular processes such as differentiation and development, allowing precise control of gene activity in response to various signals. LSD1 contains a SWIRM domain, a flavin adenine dinucleotide (FAD)-binding motif, and an amine oxidase domain, which are essential for enzymatic function. LSD1 interacts with CoREST, a corepressor that enhances demethylation activity and protects against degradation, highlighting the importance of protein-protein interactions in modulating function. |
