| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 135 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PTPN14 Rabbit Polyclonal Antibody detects endogenous levels of PTPN14 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PTPN14 also known as PTN14, PEZ is a member of the protein tyrosine phosphatase (PTP) family. PTPN14 plays a crucial role in regulating cellular processes through its function as a protein tyrosine phosphatase. PTPN14 contains one protein tyrosine phosphatase domain and one FERM (4.1, ezrin, radixin, moesin) domain, which are essential for interactions and regulatory functions. Notably, in actively proliferating cells where cell-cell contacts are disrupted, PTPN14 can translocate to the nucleus, a process that is inhibited by TGFβ, a protein known to suppress cell proliferation. Additionally, PTPN14 localization is influenced by serum concentrations, with higher levels leading to nuclear accumulation, indicating potential involvement in cell proliferation regulation. |
