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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 57 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-XIAP (Ser87) Rabbit Polyclonal Antibody detects endogenous levels of XIAP protein only when phosphorylated at Ser87. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
XIAP also known as AIP-3 is a protein that belongs to a family of apoptotic suppressor proteins. XIAP plays a crucial role in regulating apoptosis by inhibiting activated caspase-3, which is essential for cell survival during stress conditions. This function is particularly important in cancer biology, as many tumors exploit XIAP to evade programmed cell death, allowing for uncontrolled cell proliferation. Additionally, XIAP interacts with other members of the inhibitor of apoptosis protein family, such as survivin, which is expressed during the G2/M phase of the cell cycle and is involved in mitotic spindle assembly. XIAP′s ability to modulate apoptotic pathways makes XIAP a significant target for therapeutic interventions aimed at restoring apoptosis in cancer cells. |
| Product Image Gallery | |
 Western blot analysis of lysates on HepG2 cells treated with Anisomycin, using Phospho-XIAP (Ser87) Rabbit Polyclonal Antibody (EAB13569) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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