| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 261 | Human, Mouse |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Aggrecan Rabbit Polyclonal Antibody detects endogenous levels of Aggrecan protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Aggrecan also known as ACAN is a member of the aggrecan/versican proteoglycan family. Aggrecan plays a crucial role in maintaining the structural integrity and resilience of cartilage. aggrecan protein is primarily located in the extracellular matrix of cartilage, where aggrecan forms aggregates with hyaluronan and link proteins, contributing to the tissue′s compressive strength and ability to withstand mechanical stress. This localization is vital for proper cartilage functioning, as aggrecan interacts with collagen fibers, providing necessary support and cushioning in joints. Notably, aggrecan degradation is often associated with various forms of inflammatory arthritis, leading to cartilage damage and loss, which underscores the significance of monitoring aggrecan levels in clinical settings. |
| Product Image Gallery | |
 Western blot analysis of extracts on HL60, HepG2, Mouse liver cells, using Aggrecan Rabbit Polyclonal Antibody (EAB13661) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 261 kDa; Observed band size: 100 kDa |
