| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF/ICC, ELISA | 80 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | BAP1 Rabbit Polyclonal Antibody detects endogenous levels of BAP1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
BAP1 also known as UCHL2 belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. BAP1 plays a significant role in the regulation of protein degradation and cellular signaling pathways. This function is vital for maintaining cellular homeostasis and preventing tumorigenesis, as BAP1 helps to modulate the activity of various substrates involved in cell cycle regulation and DNA repair. The interaction of BAP1 with BRCA1 is particularly important, as BAP1 enhances BRCA1-mediated cell growth suppression, thereby contributing to the tumor-suppressive functions of the BRCA1-BAP1 complex. Additionally, BAP1 interacts with several other proteins, including the histone deubiquitinase complex, which further underscores BAP1′s role in epigenetic regulation and cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on MCF7, A549, Mouse testis cells, using BAP1 Rabbit Polyclonal Antibody (EAB13690) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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