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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 69 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | β-TrCP Rabbit Polyclonal Antibody detects endogenous levels of β-TrCP protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
β-TrCP also known as FBW1A, BTRC is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. β-TrCP plays a crucial role in the ubiquitin-proteasome pathway, functioning as a substrate recognition subunit of ubiquitin ligases. β-TrCP protein is essential for the regulation of various cellular processes, including the degradation of key regulatory proteins such as CD4, IkB, and β-catenin, which are involved in cell signaling and proliferation. β-TrCP-mediated ubiquitination of these proteins is vital for maintaining cellular homeostasis and preventing aberrant signaling that could lead to diseases such as cancer. β-TrCP′s interaction with other proteins, including HOS (homologous to Slimb), highlights β-TrCP′s importance in the complex network of protein degradation and regulation within the cell. |
| Product Image Gallery | |
 Western blot analysis of extracts on HuvEc cells, using β-TrCP Rabbit Polyclonal Antibody (EAB13693) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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