| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 31 | Human, Mouse, Monkey |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CD40 Rabbit Polyclonal Antibody detects endogenous levels of CD40 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CD40 also known as TNFRSF5 is a member of the TNF-receptor superfamily. CD40 plays a vital role in the activation and proliferation of these immune cells in response to signals from activated T helper cells. The interaction between CD40 and CD40L is essential for initiating a cascade of intracellular signaling that leads to B cell activation, immunoglobulin class switching, and the production of antibodies, including IgE. This process is particularly important in the context of immune responses to pathogens and in the regulation of allergic reactions. Additionally, CD40 is involved in various post-translational modifications, including ubiquitination, which can influence CD40′s stability and signaling capacity. Understanding these modifications is critical, as modifications can affect the overall immune response and the development of certain diseases, including autoimmune disorders and cancers. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293, COS7, Jurkat cells, using CD40 Rabbit Polyclonal Antibody (EAB13734) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemistry of paraffin-embedded Human liver cancer tissue, using CD40 Rabbit Polyclonal Antibody (EAB13734) at 1:100 dilution.
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