| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 65 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Factor I Rabbit Polyclonal Antibody detects endogenous levels of Factor I protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Factor I also known as CFI is a serine proteinase that is essential for regulating the complement cascade. Factor I plays a crucial role in the regulation of the complement system, which is essential for both innate and adaptive immunity. This serine protease modulates the complement cascade by cleaving C3b and C4b, thereby preventing excessive inflammation and tissue damage. Factor I primarily circulates in the plasma as a heavily N-glycosylated heterodimer composed of two disulfide-linked chains, each adorned with three N-linked oligosaccharide chains. These glycosylations are vital for Factor I′s interactions with natural substrates and cofactors during catalysis. Factor I requires protein cofactors such as Factor H, CR1, or MCP for the cleavage of C3b, and C4bp or CR1 for the cleavage of C4b, highlighting the importance of these interactions in maintaining immune homeostasis. |
