| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 51 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CRBN Rabbit Polyclonal Antibody detects endogenous levels of CRBN protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CRBN also known as cereblon is a protein related to the Lon protease protein family. CRBN is a substrate receptor of the CUL4–DDB1 E3 ubiquitin ligase complex that controls protein homeostasis by directing specific targets for ubiquitination and proteasomal turnover. Through regulation of ubiquitin-dependent degradation, CRBN influences transcriptional programs, cell-cycle progression, and cellular stress responses, linking it to pathways that shape differentiation and immune signaling. CRBN has been studied in the context of developmental biology and neuronal function, and perturbation of its expression or activity is associated with altered proteostasis and disease-relevant phenotypes. |
| Product Image Gallery | |
 Western blot analysis of extracts on A549, Mouse spleen cells, using CRBN Rabbit Polyclonal Antibody (EAB13778) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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