| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IF/ICC, ELISA | 55 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IF/ICC=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Cathepsin A Rabbit Polyclonal Antibody detects endogenous levels of Cathepsin A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Cathepsin A also known as CTSA is a member of the peptidase S10 family of serine carboxypeptidases. Cathepsin A plays a crucial role in lysosomal function by forming a high molecular weight complex with β-galactosidase and α-neuraminidase, thereby protecting these enzymes from degradation within the lysosome. This protective mechanism is vital for maintaining cellular metabolism and ensuring proper peptide biosynthesis and protein degradation. Deficiencies in cathepsin A can lead to a cascade of issues, including the dysfunction of β-galactosidase and α-neuraminidase, which are essential for the breakdown of glycoproteins and glycolipids. The gene encoding human cathepsin A is located on chromosome 20q13.12, and mutations in this gene are associated with galactosialidosis, a lysosomal storage disorder characterized by the accumulation of undegraded substrates due to the deficiencies of these critical enzymes. |
| Product Image Gallery | |
 Western blot analysis of extracts on DU145, Mouse kidney cells, using Cathepsin A Rabbit Polyclonal Antibody (EAB13788) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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