| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 60 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | CYP1B1 Rabbit Polyclonal Antibody detects endogenous levels of CYP1B1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
CYP1B1(Cytochrome P450 1B1) is a member of the cytochrome P450 superfamily of enzymes. CYP1B1 plays a crucial role in the metabolism of estrogens, particularly in the conversion of 17-beta-estradiol into catechol estrogen metabolites, such as 2-hydroxyestradiol and 4-hydroxyestradiol, which have been implicated in the development of breast cancer. CYP1B1 activity is significant because these metabolites can form DNA adducts, leading to mutations and potentially initiating carcinogenesis in mammary tissues. CYP1B1 is the predominant member of the cytochrome P450 family expressed in normal breast tissue and is upregulated in breast cancer, highlighting CYP1B1′s importance in both normal physiology and disease states. |
| Product Image Gallery | |
 Western blot analysis of extracts on Jurkat cells, using CYP1B1 Rabbit Polyclonal Antibody (EAB13806) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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