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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 46 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DDB2 Rabbit Polyclonal Antibody detects endogenous levels of DDB2 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DDB2 is a protein that is necessary for the repair of ultraviolet light-damaged DNA. DDB2 plays a crucial role in the cellular response to DNA damage, particularly damage induced by ultraviolet light. DDB2 forms a heterodimer with DDB1, collectively known as the DDB complex, which is essential for recognizing and binding to damaged DNA, specifically cyclobutane pyrimidine dimers. This interaction is vital for initiating nucleotide excision repair, a critical process that maintains genomic integrity and prevents mutations that can lead to cancer. Mutations in DDB2 are associated with xeroderma pigmentosum group E, a genetic disorder characterized by extreme sensitivity to sunlight and a significantly increased risk of skin cancer, underscoring DDB2′s importance in DNA repair mechanisms. |
| Product Image Gallery | |
 Western blot analysis of extracts on K562 cells, using DDB2 Rabbit Polyclonal Antibody (EAB13818) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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