| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 111 | Human, Mouse, Rat |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB(Westem Blotting) IHC-P(Immunohistochemistry-Paraffin) IF/ICC(Immunofluorescence/Immunocytochemistry) ELISA(Enzyme-linked Immunosorbent Assay) |
WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | DPYD Rabbit Polyclonal Antibody detects endogenous levels of DPYD protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
DPYD is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. DPYD plays a crucial role in the metabolism of pyrimidines, catalyzing the first rate-limiting step in the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine. DPYD deficiency can lead to the accumulation of uracil and thymine, potentially contributing to neurological disorders and posing significant risks for cancer patients undergoing treatment with certain pyrimidine analogs. DPYD is integral to the metabolic pathway of the anticancer drug 5-fluorouracil (5-FU), influencing both efficacy and potential toxicity. Variations in DPYD expression can occur due to transcriptional changes, such as hypermethylation of the DPYD promoter, which can downregulate enzyme expression. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2 cells, using DPYD Rabbit Polyclonal Antibody (EAB13834) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
 Immunohistochemical analysis of paraffin-embedded Mouse lung tissue, using DPYD Rabbit Polyclonal Antibody (EAB13834) at 1:100 dilution.
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