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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 24 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
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| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Endothelin-1 Rabbit Polyclonal Antibody detects endogenous levels of Endothelin-1 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Endothelin-1 also known as ET-1, EDN-1 is a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. Endothelin-1 plays a crucial role in regulating vascular tone and blood pressure. Endothelin-1 function is vital as this peptide influences cardiovascular health, and dysregulation of endothelin-1 levels has been implicated in various pathological conditions, including hypertension and heart failure. Endothelin-1 production is tightly controlled, as this peptide is generated from a larger precursor known as big-endothelin through the action of endothelin-converting enzymes. Endothelin-1′s ability to induce vasoconstriction is mediated through interaction with specific receptor subtypes, ETA and ETB, which exhibit different affinities for the various endothelin isopeptides. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T, Mouse lung cells, using Endothelin-1 Rabbit Polyclonal Antibody (EAB13852) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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