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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB | 67 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Factor XII/F12 Rabbit Polyclonal Antibody detects endogenous levels of Factor XII/F12 protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
Factor XII also known as Hageman factor, F12 plays a crucial role in initiating the intrinsic pathway of blood coagulation, vital for hemostasis following vascular injury. Upon activation, Factor XII undergoes a conformational change that allows interaction with negatively charged surfaces, leading to Factor XI activation and subsequently triggering a cascade of proteolytic events that culminate in fibrin clot formation. This process is essential for preventing excessive bleeding and ensuring proper wound healing. Additionally, Factor XII has been implicated in various pathological conditions, including thrombosis and inflammation, making Factor XII a significant target for therapeutic interventions. |
| Product Image Gallery | |
 Western blot analysis of extracts on HepG2, Mouse liver cells, using Factor XII/F12 Rabbit Polyclonal Antibody (EAB13866) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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