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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, IHC-P, IF, ELISA | 45 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
|
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | Phospho-MOR-1 (Ser375) Rabbit Polyclonal Antibody detects endogenous levels of MOR-1 protein only when phosphorylated at Ser375. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
MOR-1 also known as mu-opioid receptor, OPRM1 is one of at least three opioid receptors in humans. MOR-1 plays a crucial role in mediating the effects of endogenous opioid peptides and exogenous opiates, such as morphine, by functioning as a receptor for beta-endorphin. MOR-1 is primarily located in the central nervous system and is integral to the modulation of pain, reward, and addictive behaviors. MOR-1′s location in the cell is underscored by involvement in the inhibition of neurotransmitter release, which is achieved through the activation of G protein-coupled signaling pathways that reduce calcium ion influx and enhance potassium ion conductance. This mechanism not only influences instinctive behaviors and emotional responses but also highlights the therapeutic potential of targeting MOR-1 in pain management and addiction treatment. |
| Product Image Gallery | |
 Western blot analysis of extracts on LOVO cells, using Phospho-MOR-1 (Ser375) Rabbit Polyclonal Antibody (EAB13903) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Predicted band size: 45 kDa; Observed band size: 20-85 kDa |
