www.ebiocell.com
| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 49 | Human, Mouse, Rat |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | PXR Rabbit Polyclonal Antibody detects endogenous levels of PXR protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
PXR(Pregnane X Receptor) also known as NR1I2 is a member of the nuclear receptor superfamily. PXR plays a crucial role in the regulation of gene expression by acting as a sensor for a wide range of endogenous and exogenous compounds, including steroids and drugs. Located primarily in the nucleus, PXR functions as a transcription factor that, upon binding to ligands, forms a heterodimer with retinoid X receptor (RXR) and subsequently binds to specific DNA sequences to modulate the expression of target genes involved in drug metabolism and transport. This localization enables PXR to directly influence cellular response to various substances, thereby playing a significant role in pharmacogenomics and the body′s ability to process medications. |
| Product Image Gallery | |
 Western blot analysis of extracts on CACO2, Rat Intestine cells, using PXR Rabbit Polyclonal Antibody (EAB13938) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
|
