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| Host / Isotype | Clonality | Applications | MW (kDa) | Reactivity |
| Rabbit IgG | Polyclonal | WB, ELISA | 145 | Human, Mouse |
| Applications Dilutions | |
| The application notes include recommended starting dilutions;optimal dilutions/concentrations should be detemined by the end user. | |
| WB=1:500-2000 | |
| Application Key | WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
| Reactivity Key | H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
| Product Information | |
| Conjugate | Unconjugate |
| Specificity | SIN3A Rabbit Polyclonal Antibody detects endogenous levels of SIN3A protein. |
| Purification | Affinity purification |
| Concentration | 1mg/ml |
| Format | Liquid |
| Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
| Shipping | Gel Pack |
| Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
| UniProt ID | |
| Entrez Gene ID | |
| Product Description | |
SIN3A is a transcriptional regulatory protein that plays a crucial role in the regulation of gene expression, particularly in cell proliferation and differentiation, by functioning as a corepressor in transcriptional regulation. SIN3A interacts with the Mad family of proteins, which are essential for the repression of target genes when bound to the Myc-Max heterodimer. This interaction helps maintain the balance between cell growth and differentiation, preventing uncontrolled proliferation that can lead to tumorigenesis. SIN3A contains four conserved paired amphipathic helix (PAH) domains, which are important for interaction with Mad proteins, specifically through the second PAH domain (PAH2). By tethering SIN3A to DNA, the Mad-Max heterodimers effectively repress transcription, highlighting mSin3A′s importance in cellular processes and potential implications in cancer biology. |
| Product Image Gallery | |
 Western blot analysis of extracts on 293T cells, using SIN3A Rabbit Polyclonal Antibody (EAB13980) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
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